Cell : The Lancet - Translational Medicine

Speaker

Timothy Ray BROWN, Timothy Ray Brown Foundation of the World AIDS Institute

Timothy Ray BROWNTimothy Ray Brown (“the Berlin Patient”) is the first person cured of HIV.  His story — arguably one of the most fascinating and followed in the realm of HIV research — began in 1995 when he was diagnosed with HIV while attending school in Berlin. For the next 11 years, doctors treated him with anti-retroviral therapy.

In 2006, however, Timothy was diagnosed with acute myeloid leukemia — and underwent chemotherapy. While the first round of treatment appeared to work, it also made him more susceptible to infections. Brown developed pneumonia early on in his treatment, and he battled sepsis halfway through his third round of chemo. His doctors realized they would have to try a different approach.

His oncologist, Dr. Gero Huetter of the Charite Hospital in Berlin, opted to give Brown a stem cell transplant to treat his leukemia. But rather than choosing a matched donor, he used the stem cells of a donor he found who had what is known as a CCR5 mutation — a genetic mutation that makes cells immune to HIV. The transplant not only treated Brown’s leukemia but also eliminated HIV from his system. He was cured.

Timothy has decided to become a leader in the search for a cure.  The Timothy Ray Brown Foundation of the World AIDS Institute launched on July 24, 2012 during the XIX International AIDS conference and is the first and only organization over the 31-year history of AIDS whose sole mission is to find a cure for HIV. Timothy is Co-Founder of the World AIDS Institute.

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Elsevier
Journal - The Lancet
Journal - Cell
Elsevier

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Timothy Ray Brown
World AIDS Institute